The main objective of the project is to develop new and effective methods for obtaining active catalysts for cross-combination reactions from air-stable Ni(II) compounds. Nickel-catalyzed reactions of arylation, amination, formation of esters, thiolation, etc. will be studied as models. The main approach of the project is to introduce an additional stage of catalyst activation before conducting a catalytic reaction  The activation stage of Ni(II) complexes is planned to be carried out using electrochemistry methods or environmentally safe and stable reducing agents (formates, alcoholates, alcohols, etc.), which were not previously used in this type of cross-combination reactions.

Expected results

Transformations of Ni(II) complexes under the action of an electric current will be studied, it is established

the structure of the main products of transformations.

Electrocatalytic reactions of the formation of C-C and C-heteroatom bonds (CH-activation reactions, Mizoroki-Heck, Buchwald-Hartwig reactions, the formation of esters) will be investigated.,

thiolation, etc.) with the participation of Ni(II) complexes, which will include ligands of different types (amines, phosphines or carbenes). Optimal parameters of the electrochemical cell for cross-combination reactions will be found.

The main patterns reflecting the influence of various parameters will be established

the ligand environment of the nickel catalyst and reaction conditions (temperature, solvent,

chemical additives, etc.) on the activity of the catalytic system in the reactions of the formation of C-C and C-heteroatom bonds (CH-activation reactions, Mizoroki-Heck, Buchwald-Hartwig reactions, formation

esters, thiolation, etc.).

New efficient electrocatalytic systems based on Ni(II) complexes will be developed

(with amine, phosphine or carbene ligands) having high activity,

stability of catalytic properties and selectivity in typical C-C and C-heteroatom bond formation reactions (CH-activation reactions, Mizoroki-Heck, Buchwald-Hartwig reactions, formation

esters, hydrothyolation, etc.).