The project is aimed at solving the fundamental problem of creating efficient catalytic systems for the synthesis of liquid hydrocarbons from CO and H2 with a given fractional and group composition on multifunctional catalytic systems. One of the central problems of the synthesis of hydrocarbons by the Fischer-Tropsch (FT) method is the wide molecular mass distribution (MMR) of products, which imposes a restriction on the fractional composition of the resulting hydrocarbons. Thus, the maximum content of the gasoline fraction cannot exceed 48%, diesel – 38%. The use of multifunctional catalytic systems, which simultaneously allow not only the synthesis of hydrocarbons, but also their secondary transformations – hydrocracking, hydroisomerization, aclkylation, etc., makes it possible to change the MMR of products towards the desired fraction of hydrocarbons and purposefully obtain products with the required composition and properties in one reactor. An example of such a catalytic system is a combination of catalysts for the synthesis of FT and zeolites – catalysts for hydrocracking and hydroisomerization of hydrocarbons. Systematic studies of multifunctional catalytic systems for the production of synthetic hydrocarbons from synthesis gas at pressures up to 6.0 MPa carried out within the framework of this project allowed us to establish new fundamental laws reflecting the relationship between the nature of multifunctional catalysts, their activation methods and the selectivity of the process.